A Twin Otter aircraft belonging to Tara Air of Nepal has been missing since Wednesday 3:08 pm from Khotang.
Along with Captain Anup Raj Shakya, Co-pilot Sachindra Shrestha and Air Hostess Sudiksha Gurung, there were 18 Bhutanese and one foreigner in the flight, the airline said.
The Bhutanese were in Nepal to take part in the SAARC Trade Fair in Kathmandu, it is learnt.
Details are awaited.